High-affinity ligands of the colchicine domain in tubulin based on a structure-guided design

Microtubule-targeting agents that bind at the colchicine-site of tubulin are of particular interest in antitumoral therapy due to their dual mechanism of action as antimitotics and vascular disrupting agents. Cyclohexanediones derivatives have been described as a new family of colchicine-domain bind...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Sci Rep
Päätekijät: Bueno, Oskía, Estévez Gallego, Juan, Martins, Solange, Prota, Andrea E., Gago, Federico, Gómez-SanJuan, Asier, Camarasa, María-José, Barasoain, Isabel, Steinmetz, Michel O., Díaz, J. Fernando, Pérez-Pérez, María-Jesús, Liekens, Sandra, Priego, Eva-María
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group UK 2018
Aiheet:
Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5844890/
https://ncbi.nlm.nih.gov/pubmed/29523799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-22382-x
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