High affinity and covalent-binding microtubule stabilizing agents show activity in chemotherapy-resistant acute myeloid leukemia cells

Treatment failure in acute myeloid leukemia (AML) is frequently due to the persistence of a cell population resistant to chemotherapy through different mechanisms, in which drug efflux via ATP-binding cassette (ABC) proteins, specifically P-glycoprotein, is one of the most recognized. However, disap...

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Publicado en:Cancer Lett
Autores principales: Pera, Benet, Calvo-Vidal, M. Nieves, Ambati, Srikanth, Jordi, Michel, Kahn, Alissa, Díaz, J. Fernando, Fang, Weishuo, Altmann, Karl-Heinz, Cerchietti, Leandro, Moore, Malcolm A.S.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2015
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5019175/
https://ncbi.nlm.nih.gov/pubmed/26277539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2015.07.038
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