Zampanolide, a Microtubule-Stabilizing Agent, Is Active in Resistant Cancer Cells and Inhibits Cell Migration

Zampanolide, first discovered in a sponge extract in 1996 and later identified as a microtubule-stabilizing agent in 2009, is a covalent binding secondary metabolite with potent, low nanomolar activity in mammalian cells. Zampanolide was not susceptible to single amino acid mutations at the taxoid s...

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Veröffentlicht in:Int J Mol Sci
Hauptverfasser: Field, Jessica J., Northcote, Peter T., Paterson, Ian, Altmann, Karl-Heinz, Díaz, J. Fernando, Miller, John H.
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5454884/
https://ncbi.nlm.nih.gov/pubmed/28467385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms18050971
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