Transient Oxidative Stress Damages Mitochondrial Machinery Inducing Persistent β-Cell Dysfunction

door Li, Ning, Brun, Thierry, Cnop, Miriam, Cunha, Daniel A., Eizirik, Decio L., Maechler, Pierre
Gepubliceerd in 2009

Phenylpropenoic Acid Glucoside from Rooibos Protects Pancreatic Beta Cells against Cell Death Induced by Acute Injury

door Himpe, Eddy, Cunha, Daniel A., Song, Imane, Bugliani, Marco, Marchetti, Piero, Cnop, Miriam, Bouwens, Luc
Gepubliceerd in PLoS One (2016)

Enhanced Signaling Downstream of Ribonucleic Acid-Dependent Protein Kinase-Like Kinase Potentiates Lipotoxic Endoplasmic Reticulum Stress in Human Islets

door Ladriere, Laurence, Igoillo-Esteve, Mariana, Cunha, Daniel A., Brion, Jean-Pierre, Bugliani, Marco, Marchetti, Piero, Eizirik, Décio L., Cnop, Miriam
Gepubliceerd in Mol Endocrinol (2010)

p53 Up-regulated Modulator of Apoptosis (PUMA) Activation Contributes to Pancreatic β-Cell Apoptosis Induced by Proinflammatory Cytokines and Endoplasmic Reticulum Stress

door Gurzov, Esteban N., Germano, Carla M., Cunha, Daniel A., Ortis, Fernanda, Vanderwinden, Jean-Marie, Marchetti, Piero, Zhang, Lin, Eizirik, Decio L.
Gepubliceerd in 2010

Glucagon-Like Peptide-1 Agonists Protect Pancreatic β-Cells From Lipotoxic Endoplasmic Reticulum Stress Through Upregulation of BiP and JunB

door Cunha, Daniel A., Ladrière, Laurence, Ortis, Fernanda, Igoillo-Esteve, Mariana, Gurzov, Esteban N., Lupi, Roberto, Marchetti, Piero, Eizirik, Décio L., Cnop, Miriam
Gepubliceerd in 2009

PTPN2, a Candidate Gene for Type 1 Diabetes, Modulates Interferon-γ–Induced Pancreatic β-Cell Apoptosis

door Moore, Fabrice, Colli, Maikel L., Cnop, Miriam, Esteve, Mariana Igoillo, Cardozo, Alessandra K., Cunha, Daniel A., Bugliani, Marco, Marchetti, Piero, Eizirik, Décio L.
Gepubliceerd in 2009

Thrombospondin 1 protects pancreatic β-cells from lipotoxicity via the PERK–NRF2 pathway

door Cunha, Daniel A, Cito, Monia, Carlsson, Per-Ola, Vanderwinden, Jean-Marie, Molkentin, Jeffery D, Bugliani, Marco, Marchetti, Piero, Eizirik, Décio L, Cnop, Miriam
Gepubliceerd in Cell Death Differ (2016)

Cytokines Interleukin-1β and Tumor Necrosis Factor-α Regulate Different Transcriptional and Alternative Splicing Networks in Primary β-Cells

door Ortis, Fernanda, Naamane, Najib, Flamez, Daisy, Ladrière, Laurence, Moore, Fabrice, Cunha, Daniel A., Colli, Maikel L., Thykjaer, Thomas, Thorsen, Kasper, Ørntoft, Torben F., Eizirik, Decio L.
Gepubliceerd in 2010

Exposure to the Viral By-Product dsRNA or Coxsackievirus B5 Triggers Pancreatic Beta Cell Apoptosis via a Bim / Mcl-1 Imbalance

door Colli, Maikel L., Nogueira, Tatiane C., Allagnat, Florent, Cunha, Daniel A., Gurzov, Esteban N., Cardozo, Alessandra K., Roivainen, Merja, Op de beeck, Anne, Eizirik, Decio L.
Gepubliceerd in 2011

Pancreatic β-cell protection from inflammatory stress by the endoplasmic reticulum proteins thrombospondin 1 and mesencephalic astrocyte-derived neutrotrophic factor (MANF)

door Cunha, Daniel A., Cito, Monia, Grieco, Fabio Arturo, Cosentino, Cristina, Danilova, Tatiana, Ladrière, Laurence, Lindahl, Maria, Domanskyi, Andrii, Bugliani, Marco, Marchetti, Piero, Eizirik, Décio L., Cnop, Miriam
Gepubliceerd in J Biol Chem (2017)

GLIS3, a Susceptibility Gene for Type 1 and Type 2 Diabetes, Modulates Pancreatic Beta Cell Apoptosis via Regulation of a Splice Variant of the BH3-Only Protein Bim

door Nogueira, Tatiane C., Paula, Flavia M., Villate, Olatz, Colli, Maikel L., Moura, Rodrigo F., Cunha, Daniel A., Marselli, Lorella, Marchetti, Piero, Cnop, Miriam, Julier, Cécile, Eizirik, Decio L.
Gepubliceerd in 2013

Age-dependent changes in rat lacrimal gland anti-oxidant and vesicular related protein expression profiles

door Batista, Thiago Martins, Tomiyoshi, Lilian Midori, Dias, Ana Carolina, Roma, Letícia Prates, Módulo, Carolina Maria, Malki, Leonardo Tannus, Filho, Elísio Bueno Machado, Deminice, Rafael, Jordão, Alceu Afonso, Cunha, Daniel A., Rocha, Eduardo Melani
Gepubliceerd in 2012

Combined transcriptome and proteome profiling of the pancreatic β-cell response to palmitate unveils key pathways of β-cell lipotoxicity

door Lytrivi, Maria, Ghaddar, Kassem, Lopes, Miguel, Rosengren, Victoria, Piron, Anthony, Yi, Xiaoyan, Johansson, Henrik, Lehtiö, Janne, Igoillo-Esteve, Mariana, Cunha, Daniel A., Marselli, Lorella, Marchetti, Piero, Ortsäter, Henrik, Eizirik, Decio L., Cnop, Miriam
Gepubliceerd in BMC Genomics (2020)

Nova1 is a master regulator of alternative splicing in pancreatic beta cells

door Villate, Olatz, Turatsinze, Jean-Valery, Mascali, Loriana G., Grieco, Fabio A., Nogueira, Tatiane C., Cunha, Daniel A., Nardelli, Tarlliza R., Sammeth, Michael, Salunkhe, Vishal A., Esguerra, Jonathan L. S., Eliasson, Lena, Marselli, Lorella, Marchetti, Piero, Eizirik, Decio L.
Gepubliceerd in 2014

A Missense Mutation in PPP1R15B Causes a Syndrome Including Diabetes, Short Stature, and Microcephaly

door Abdulkarim, Baroj, Nicolino, Marc, Igoillo-Esteve, Mariana, Daures, Mathilde, Romero, Sophie, Philippi, Anne, Senée, Valérie, Lopes, Miguel, Cunha, Daniel A., Harding, Heather P., Derbois, Céline, Bendelac, Nathalie, Hattersley, Andrew T., Eizirik, Décio L., Ron, David, Cnop, Miriam, Julier, Cécile
Gepubliceerd in Diabetes (2015)

DNA methylation profiling identifies epigenetic dysregulation in pancreatic islets from type 2 diabetic patients

door Volkmar, Michael, Dedeurwaerder, Sarah, Cunha, Daniel A, Ndlovu, Matladi N, Defrance, Matthieu, Deplus, Rachel, Calonne, Emilie, Volkmar, Ute, Igoillo-Esteve, Mariana, Naamane, Najib, Del Guerra, Silvia, Masini, Matilde, Bugliani, Marco, Marchetti, Piero, Cnop, Miriam, Eizirik, Decio L, Fuks, François
Gepubliceerd in 2012

Death Protein 5 and p53-Upregulated Modulator of Apoptosis Mediate the Endoplasmic Reticulum Stress–Mitochondrial Dialog Triggering Lipotoxic Rodent and Human β-Cell Apoptosis

door Cunha, Daniel A., Igoillo-Esteve, Mariana, Gurzov, Esteban N., Germano, Carla M., Naamane, Najib, Marhfour, Ihsane, Fukaya, Makiko, Vanderwinden, Jean-Marie, Gysemans, Conny, Mathieu, Chantal, Marselli, Lorella, Marchetti, Piero, Harding, Heather P., Ron, David, Eizirik, Décio L., Cnop, Miriam
Gepubliceerd in 2012

Initiation and execution of lipotoxic ER stress in pancreatic β-cells

door Cunha, Daniel A., Hekerman, Paul, Ladrière, Laurence, Bazarra-Castro, Angie, Ortis, Fernanda, Wakeham, Marion C., Moore, Fabrice, Rasschaert, Joanne, Cardozo, Alessandra K., Bellomo, Elisa, Overbergh, Lutgart, Mathieu, Chantal, Lupi, Roberto, Hai, Tsonwin, Herchuelz, Andre, Marchetti, Piero, Rutter, Guy A., Eizirik, Décio L., Cnop, Miriam
Gepubliceerd in 2008