Initiation and execution of lipotoxic ER stress in pancreatic β-cells

Free fatty acids (FFA) cause apoptosis of pancreatic β-cells and might contribute to β-cell loss in type 2 diabetes via the induction of endoplasmic reticulum (ER) stress. We studied here the molecular mechanisms implicated in FFA-induced ER stress initiation and apoptosis in INS-1E cells, FACS-puri...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Cunha, Daniel A., Hekerman, Paul, Ladrière, Laurence, Bazarra-Castro, Angie, Ortis, Fernanda, Wakeham, Marion C., Moore, Fabrice, Rasschaert, Joanne, Cardozo, Alessandra K., Bellomo, Elisa, Overbergh, Lutgart, Mathieu, Chantal, Lupi, Roberto, Hai, Tsonwin, Herchuelz, Andre, Marchetti, Piero, Rutter, Guy A., Eizirik, Décio L., Cnop, Miriam
Médium: Artigo
Jazyk:Inglês
Vydáno: 2008
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3675788/
https://ncbi.nlm.nih.gov/pubmed/18559892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.026062
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky