Initiation and execution of lipotoxic ER stress in pancreatic β-cells

Free fatty acids (FFA) cause apoptosis of pancreatic β-cells and might contribute to β-cell loss in type 2 diabetes via the induction of endoplasmic reticulum (ER) stress. We studied here the molecular mechanisms implicated in FFA-induced ER stress initiation and apoptosis in INS-1E cells, FACS-puri...

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Detalhes bibliográficos
Main Authors: Cunha, Daniel A., Hekerman, Paul, Ladrière, Laurence, Bazarra-Castro, Angie, Ortis, Fernanda, Wakeham, Marion C., Moore, Fabrice, Rasschaert, Joanne, Cardozo, Alessandra K., Bellomo, Elisa, Overbergh, Lutgart, Mathieu, Chantal, Lupi, Roberto, Hai, Tsonwin, Herchuelz, Andre, Marchetti, Piero, Rutter, Guy A., Eizirik, Décio L., Cnop, Miriam
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3675788/
https://ncbi.nlm.nih.gov/pubmed/18559892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.026062
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