Thrombospondin 1 protects pancreatic β-cells from lipotoxicity via the PERK–NRF2 pathway

The failure of β-cells has a central role in the pathogenesis of type 2 diabetes, and the identification of novel approaches to improve functional β-cell mass is essential to prevent/revert the disease. Here we show a critical novel role for thrombospondin 1 (THBS1) in β-cell survival during lipotox...

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Vydáno v:Cell Death Differ
Hlavní autoři: Cunha, Daniel A, Cito, Monia, Carlsson, Per-Ola, Vanderwinden, Jean-Marie, Molkentin, Jeffery D, Bugliani, Marco, Marchetti, Piero, Eizirik, Décio L, Cnop, Miriam
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2016
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Original Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5136495/
https://ncbi.nlm.nih.gov/pubmed/27588705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2016.89
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