Thrombospondin 1 protects pancreatic β-cells from lipotoxicity via the PERK–NRF2 pathway

The failure of β-cells has a central role in the pathogenesis of type 2 diabetes, and the identification of novel approaches to improve functional β-cell mass is essential to prevent/revert the disease. Here we show a critical novel role for thrombospondin 1 (THBS1) in β-cell survival during lipotox...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Cell Death Differ
Main Authors: Cunha, Daniel A, Cito, Monia, Carlsson, Per-Ola, Vanderwinden, Jean-Marie, Molkentin, Jeffery D, Bugliani, Marco, Marchetti, Piero, Eizirik, Décio L, Cnop, Miriam
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
Assuntos:
Original Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5136495/
https://ncbi.nlm.nih.gov/pubmed/27588705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2016.89
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados