Glucagon-Like Peptide-1 Agonists Protect Pancreatic β-Cells From Lipotoxic Endoplasmic Reticulum Stress Through Upregulation of BiP and JunB

OBJECTIVE: Chronic exposure of pancreatic β-cells to saturated free fatty acids (FFAs) causes endoplasmic reticulum (ER) stress and apoptosis and may contribute to β-cell loss in type 2 diabetes. Here, we evaluated the molecular mechanisms involved in the protection of β-cells from lipotoxic ER stre...

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Hlavní autoři: Cunha, Daniel A., Ladrière, Laurence, Ortis, Fernanda, Igoillo-Esteve, Mariana, Gurzov, Esteban N., Lupi, Roberto, Marchetti, Piero, Eizirik, Décio L., Cnop, Miriam
Médium: Artigo
Jazyk:Inglês
Vydáno: American Diabetes Association 2009
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2780890/
https://ncbi.nlm.nih.gov/pubmed/19720788
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db09-0685
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