ER stress and the decline and fall of pancreatic beta cells in type 1 diabetes

Por Brozzi, Flora, Eizirik, Décio L.
Publicado no Ups J Med Sci (2016)

On the Immense Variety and Complexity of Circumstances Conditioning Pancreatic β-Cell Apoptosis in Type 1 Diabetes

Por Eizirik, Decio L., Grieco, Fabio A.
Publicado em 2012

Viral infections in type 1 diabetes mellitus — why the β cells?

Por de Beeck, Anne Op, Eizirik, Decio L.
Publicado no Nat Rev Endocrinol (2016)

In silico identification of NF-kappaB-regulated genes in pancreatic beta-cells

Por Naamane, Najib, van Helden, Jacques, Eizirik, Decio L
Publicado em 2007

Alternative splicing: the new frontier in diabetes research

Por Juan-Mateu, Jonàs, Villate, Olatz, Eizirik, Décio L
Publicado no Eur J Endocrinol (2015)

Clic4, a novel protein that sensitizes β-cells to apoptosis()

Por Patel, Dhaval, Ythier, Damien, Brozzi, Flora, Eizirik, Decio L., Thorens, Bernard
Publicado no Mol Metab (2015)

JunB Inhibits ER Stress and Apoptosis in Pancreatic Beta Cells

Por Gurzov, Esteban N., Ortis, Fernanda, Bakiri, Latifa, Wagner, Erwin F., Eizirik, Decio L.
Publicado em 2008

MDA5 and PTPN2, two candidate genes for type 1 diabetes, modify pancreatic β-cell responses to the viral by-product double-stranded RNA

Por Colli, Maikel L., Moore, Fabrice, Gurzov, Esteban N., Ortis, Fernanda, Eizirik, Decio L.
Publicado em 2010

Transient Oxidative Stress Damages Mitochondrial Machinery Inducing Persistent β-Cell Dysfunction

Por Li, Ning, Brun, Thierry, Cnop, Miriam, Cunha, Daniel A., Eizirik, Decio L., Maechler, Pierre
Publicado em 2009

Exposure of human islets to cytokines can result in disproportionately elevated proinsulin release

Por Hostens, Katleen, Pavlovic, Dejan, Zambre, Yasmeeni, Ling, Zhidong, Van Schravendijk, Christiaan, Eizirik, Décio L., Pipeleers, Daniel G.
Publicado em 1999

Construction and validation of the APOCHIP, a spotted oligo-microarray for the study of beta-cell apoptosis

Por Magnusson, Nils E, Cardozo, Alessandra K, Kruhøffer, Mogens, Eizirik, Decio L, Ørntoft, Torben F, Jensen, Jens L
Publicado em 2005

PTPN2, a Candidate Gene for Type 1 Diabetes, Modulates Pancreatic β-Cell Apoptosis via Regulation of the BH3-Only Protein Bim

Por Santin, Izortze, Moore, Fabrice, Colli, Maikel L., Gurzov, Esteban N., Marselli, Lorella, Marchetti, Piero, Eizirik, Decio L.
Publicado em 2011

The Transcription Factor C/EBP delta Has Anti-Apoptotic and Anti-Inflammatory Roles in Pancreatic Beta Cells

Por Moore, Fabrice, Santin, Izortze, Nogueira, Tatiane C., Gurzov, Esteban N., Marselli, Lorella, Marchetti, Piero, Eizirik, Decio L.
Publicado em 2012

Restoration of the Unfolded Protein Response in Pancreatic β Cells Protects Mice Against Type 1 Diabetes

Por Engin, Feyza, Yermalovich, Alena, Nguyen, True, Hummasti, Sarah, Fu, Wenxian, Eizirik, Decio L., Mathis, Diane, Hotamisligil, Gökhan S.
Publicado em 2013

Strain Differences Determine the Suitability of Animal Models for Noninvasive In Vivo Beta Cell Mass Determination with Radiolabeled Exendin

Por Willekens, Stefanie M. A., Joosten, Lieke, Boerman, Otto C., Balhuizen, Alexander, Eizirik, Decio L., Gotthardt, Martin, Brom, Maarten
Publicado no Mol Imaging Biol (2016)

Detailed transcriptome atlas of the pancreatic beta cell

Por Kutlu, Burak, Burdick, David, Baxter, David, Rasschaert, Joanne, Flamez, Daisy, Eizirik, Decio L, Welsh, Nils, Goodman, Nathan, Hood, Leroy
Publicado em 2009

p53 Up-regulated Modulator of Apoptosis (PUMA) Activation Contributes to Pancreatic β-Cell Apoptosis Induced by Proinflammatory Cytokines and Endoplasmic Reticulum Stress

Por Gurzov, Esteban N., Germano, Carla M., Cunha, Daniel A., Ortis, Fernanda, Vanderwinden, Jean-Marie, Marchetti, Piero, Zhang, Lin, Eizirik, Decio L.
Publicado em 2010

Glucagon-Like Peptide-1 Agonists Protect Pancreatic β-Cells From Lipotoxic Endoplasmic Reticulum Stress Through Upregulation of BiP and JunB

Por Cunha, Daniel A., Ladrière, Laurence, Ortis, Fernanda, Igoillo-Esteve, Mariana, Gurzov, Esteban N., Lupi, Roberto, Marchetti, Piero, Eizirik, Décio L., Cnop, Miriam
Publicado em 2009

Pancreatic α Cells are Resistant to Metabolic Stress-induced Apoptosis in Type 2 Diabetes

Por Marroqui, Laura, Masini, Matilde, Merino, Beatriz, Grieco, Fabio A., Millard, Isabelle, Dubois, Christine, Quesada, Ivan, Marchetti, Piero, Cnop, Miriam, Eizirik, Decio L.
Publicado no EBioMedicine (2015)

PTPN2, a Candidate Gene for Type 1 Diabetes, Modulates Interferon-γ–Induced Pancreatic β-Cell Apoptosis

Por Moore, Fabrice, Colli, Maikel L., Cnop, Miriam, Esteve, Mariana Igoillo, Cardozo, Alessandra K., Cunha, Daniel A., Bugliani, Marco, Marchetti, Piero, Eizirik, Décio L.
Publicado em 2009