PTPN2, a Candidate Gene for Type 1 Diabetes, Modulates Pancreatic β-Cell Apoptosis via Regulation of the BH3-Only Protein Bim

OBJECTIVE: Genome-wide association studies allowed the identification of several associations between specific loci and type 1 diabetes (T1D). However, the mechanisms by which most candidate genes predispose to T1D remain unclear. We presently evaluated the mechanisms by which PTPN2, a candidate gen...

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Detalhes bibliográficos
Main Authors: Santin, Izortze, Moore, Fabrice, Colli, Maikel L., Gurzov, Esteban N., Marselli, Lorella, Marchetti, Piero, Eizirik, Decio L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2011
Assuntos:
Genetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3219938/
https://ncbi.nlm.nih.gov/pubmed/21984578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db11-0758
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