GLIS3, a Susceptibility Gene for Type 1 and Type 2 Diabetes, Modulates Pancreatic Beta Cell Apoptosis via Regulation of a Splice Variant of the BH3-Only Protein Bim

Mutations in human Gli-similar (GLIS) 3 protein cause neonatal diabetes. The GLIS3 gene region has also been identified as a susceptibility risk locus for both type 1 and type 2 diabetes. GLIS3 plays a role in the generation of pancreatic beta cells and in insulin gene expression, but there is no in...

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Autors principals: Nogueira, Tatiane C., Paula, Flavia M., Villate, Olatz, Colli, Maikel L., Moura, Rodrigo F., Cunha, Daniel A., Marselli, Lorella, Marchetti, Piero, Cnop, Miriam, Julier, Cécile, Eizirik, Decio L.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2013
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Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3667755/
https://ncbi.nlm.nih.gov/pubmed/23737756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1003532
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