p53 Up-regulated Modulator of Apoptosis (PUMA) Activation Contributes to Pancreatic β-Cell Apoptosis Induced by Proinflammatory Cytokines and Endoplasmic Reticulum Stress

Type 1 diabetes is an autoimmune disorder characterized by chronic inflammation and pancreatic β-cell loss. Here, we demonstrate that the proinflammatory cytokine interleukin-1β, combined with interferon-γ, induces the expression of the Bcl-2 homology 3 (BH3)-only activator PUMA (p53 up-regulated mo...

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Hlavní autoři: Gurzov, Esteban N., Germano, Carla M., Cunha, Daniel A., Ortis, Fernanda, Vanderwinden, Jean-Marie, Marchetti, Piero, Zhang, Lin, Eizirik, Decio L.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2010
Témata:
Molecular Bases of Disease
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2888402/
https://ncbi.nlm.nih.gov/pubmed/20421300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.122374
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