Death Protein 5 and p53-Upregulated Modulator of Apoptosis Mediate the Endoplasmic Reticulum Stress–Mitochondrial Dialog Triggering Lipotoxic Rodent and Human β-Cell Apoptosis

Environmental factors such as diets rich in saturated fats contribute to dysfunction and death of pancreatic β-cells in diabetes. Endoplasmic reticulum (ER) stress is elicited in β-cells by saturated fatty acids. Here we show that palmitate-induced β-cell apoptosis is mediated by the intrinsic mitoc...

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Main Authors: Cunha, Daniel A., Igoillo-Esteve, Mariana, Gurzov, Esteban N., Germano, Carla M., Naamane, Najib, Marhfour, Ihsane, Fukaya, Makiko, Vanderwinden, Jean-Marie, Gysemans, Conny, Mathieu, Chantal, Marselli, Lorella, Marchetti, Piero, Harding, Heather P., Ron, David, Eizirik, Décio L., Cnop, Miriam
Format: Artigo
Sprog:Inglês
Udgivet: American Diabetes Association 2012
Fag:
Signal Transduction
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3478544/
https://ncbi.nlm.nih.gov/pubmed/22773666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db12-0123
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