Pro-Inflammatory Cytokines Induce Insulin and Glucagon Double Positive Human Islet Cells That Are Resistant to Apoptosis

The presence of islet cells double positive for insulin and glucagon (Ins(+)/Glu(+)) has been described in the pancreas from both type 2 (T2D) and type 1 (T1D) diabetic subjects. We studied the role of pro-inflammatory cytokines on the occurrence, trajectory, and characteristics of Ins(+)/Glu(+) cel...

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Veröffentlicht in:Biomolecules
Hauptverfasser: Tesi, Marta, Bugliani, Marco, Ferri, Gianmarco, Suleiman, Mara, De Luca, Carmela, Bosi, Emanuele, Masini, Matilde, De Tata, Vincenzo, Gysemans, Conny, Cardarelli, Francesco, Cnop, Miriam, Eizirik, Decio L., Marchetti, Piero, Marselli, Lorella
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2021
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7923272/
https://ncbi.nlm.nih.gov/pubmed/33669901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biom11020320
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