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Combined transcriptome and proteome profiling of the pancreatic β-cell response to palmitate unveils key pathways of β-cell lipotoxicity
BACKGROUND: Prolonged exposure to elevated free fatty acids induces β-cell failure (lipotoxicity) and contributes to the pathogenesis of type 2 diabetes. In vitro exposure of β-cells to the saturated free fatty acid palmitate is a valuable model of lipotoxicity, reproducing features of β-cell failur...
में बचाया:
| में प्रकाशित: | BMC Genomics |
|---|---|
| मुख्य लेखकों: | , , , , , , , , , , , , , , |
| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
BioMed Central
2020
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| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7448506/ https://ncbi.nlm.nih.gov/pubmed/32847508 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12864-020-07003-0 |
| टैग : |
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