Combined transcriptome and proteome profiling of the pancreatic β-cell response to palmitate unveils key pathways of β-cell lipotoxicity

BACKGROUND: Prolonged exposure to elevated free fatty acids induces β-cell failure (lipotoxicity) and contributes to the pathogenesis of type 2 diabetes. In vitro exposure of β-cells to the saturated free fatty acid palmitate is a valuable model of lipotoxicity, reproducing features of β-cell failur...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:BMC Genomics
Egile Nagusiak: Lytrivi, Maria, Ghaddar, Kassem, Lopes, Miguel, Rosengren, Victoria, Piron, Anthony, Yi, Xiaoyan, Johansson, Henrik, Lehtiö, Janne, Igoillo-Esteve, Mariana, Cunha, Daniel A., Marselli, Lorella, Marchetti, Piero, Ortsäter, Henrik, Eizirik, Decio L., Cnop, Miriam
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: BioMed Central 2020
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7448506/
https://ncbi.nlm.nih.gov/pubmed/32847508
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12864-020-07003-0
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