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Pro-inflammatory cytokines induce cell death, inflammatory responses, and endoplasmic reticulum stress in human iPSC-derived beta cells

BACKGROUND: Adult human pancreatic beta cells are the “gold standard” for studies on diabetes pathogenesis, but their use is limited by insufficient availability and variable quality. An important effort has recently taken place to differentiate beta cells from human induced pluripotent stem cells (...

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Bibliografiske detaljer
Udgivet i:Stem Cell Res Ther
Main Authors: Demine, Stéphane, Schiavo, Andrea Alex, Marín-Cañas, Sandra, Marchetti, Piero, Cnop, Miriam, Eizirik, Decio L.
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2020
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6942385/
https://ncbi.nlm.nih.gov/pubmed/31900242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13287-019-1523-3
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