Pro-inflammatory cytokines induce cell death, inflammatory responses, and endoplasmic reticulum stress in human iPSC-derived beta cells

BACKGROUND: Adult human pancreatic beta cells are the “gold standard” for studies on diabetes pathogenesis, but their use is limited by insufficient availability and variable quality. An important effort has recently taken place to differentiate beta cells from human induced pluripotent stem cells (...

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Vydáno v:Stem Cell Res Ther
Hlavní autoři: Demine, Stéphane, Schiavo, Andrea Alex, Marín-Cañas, Sandra, Marchetti, Piero, Cnop, Miriam, Eizirik, Decio L.
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2020
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6942385/
https://ncbi.nlm.nih.gov/pubmed/31900242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13287-019-1523-3
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