Restoration of the Unfolded Protein Response in Pancreatic β Cells Protects Mice Against Type 1 Diabetes

Perturbations in endoplasmic reticulum (ER) homeostasis can evoke stress responses leading to aberrant glucose and lipid metabolism. ER dysfunction is linked to inflammatory disorders, but its role in the pathogenesis of autoimmune type 1 diabetes (T1D) remains unknown. We identified defects in the...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Engin, Feyza, Yermalovich, Alena, Nguyen, True, Hummasti, Sarah, Fu, Wenxian, Eizirik, Decio L., Mathis, Diane, Hotamisligil, Gökhan S.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2013
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4169117/
https://ncbi.nlm.nih.gov/pubmed/24225943
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3006534
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