XBP-1 is required for biogenesis of cellular secretory machinery of exocrine glands

by Lee, Ann-Hwee, Chu, Gerald C, Iwakoshi, Neal N, Glimcher, Laurie H
Published 2005

Imaging guided trials of the angiogenesis inhibitor sunitinib in mouse models predict efficacy in pancreatic neuroendocrine but not ductal carcinoma

by Olson, Peter, Chu, Gerald C., Perry, Samuel R., Nolan-Stevaux, Olivier, Hanahan, Douglas
Published 2011

Specific requirement of the chromatin modifier mSin3B in cell cycle exit and cellular differentiation

by David, Gregory, Grandinetti, Kathryn B., Finnerty, Patricia M., Simpson, Natalie, Chu, Gerald C., DePinho, Ronald A.
Published 2008

GLI1 is regulated through Smoothened-independent mechanisms in neoplastic pancreatic ducts and mediates PDAC cell survival and transformation

by Nolan-Stevaux, Olivier, Lau, Janet, Truitt, Morgan L., Chu, Gerald C., Hebrok, Matthias, Fernández-Zapico, Martin E., Hanahan, Douglas
Published 2009

Ott1 (Rbm15) Is Essential for Placental Vascular Branching Morphogenesis and Embryonic Development of the Heart and Spleen

by Raffel, Glen D., Chu, Gerald C., Jesneck, Jonathan L., Cullen, Dana E., Bronson, Roderick T., Bernard, Olivier A., Gilliland, D. Gary
Published 2009

Context-Dependent Transformation of Adult Pancreatic Cells by Oncogenic K-Ras

by Gidekel Friedlander, Sharon Y, Chu, Gerald C., Snyder, Eric L., Girnius, Nomeda, Dibelius, Gregory, Crowley, Denise, Vasile, Eliza, DePinho, Ronald A., Jacks, Tyler
Published 2009

Autophagy is critical for pancreatic tumor growth and progression in tumors with p53 alterations

by Yang, Annan, Rajeshkumar, N.V., Wang, Xiaoxu, Yabuuchi, Shinichi, Alexander, Brian M., Chu, Gerald C., Von Hoff, Daniel D., Maitra, Anirban, Kimmelman, Alec C.
Published 2014

Smad4 is dispensable for normal pancreas development yet critical in progression and tumor biology of pancreas cancer

by Bardeesy, Nabeel, Cheng, Kuang-hung, Berger, Justin H., Chu, Gerald C., Pahler, Jessica, Olson, Peter, Hezel, Aram F., Horner, James, Lauwers, Gregory Y., Hanahan, Douglas, DePinho, Ronald A.
Published 2006

Mutant N-Ras protects colorectal cancer cells from stress-induced apoptosis and contributes to cancer development and progression

by Wang, Yufang, Velho, Sérgia, Vakiani, Efsevia, Peng, Shouyong, Bass, Adam J., Chu, Gerald C., Gierut, Jessica, Bugni, James M., Der, Channing J., Philips, Mark, Solit, David B., Haigis, Kevin M.
Published 2012

Animal models of human prostate cancer: The Consensus Report of the New York Meeting of the Mouse Models of Human Cancers Consortium Prostate Pathology Committee

by Ittmann, Michael, Huang, Jiaoti, Radaelli, Enrico, Martin, Philip, Signoretti, Sabina, Sullivan, Ruth, Simons, Brian W., Ward, Jerrold M., Robinson, Brian D., Chu, Gerald C., Loda, Massimo, Thomas, George, Borowsky, Alexander, Cardiff, Robert D.
Published 2013

Both p16(Ink4a) and the p19(Arf)-p53 pathway constrain progression of pancreatic adenocarcinoma in the mouse

by Bardeesy, Nabeel, Aguirre, Andrew J., Chu, Gerald C., Cheng, Kuang-hung, Lopez, Lyle V., Hezel, Aram F., Feng, Bin, Brennan, Cameron, Weissleder, Ralph, Mahmood, Umar, Hanahan, Douglas, Redston, Mark S., Chin, Lynda, DePinho, Ronald A.
Published 2006

Transcription factor genes Smad4 and Gata4 cooperatively regulate cardiac valve development

by Moskowitz, Ivan P., Wang, Jun, Peterson, Michael A., Pu, William T., Mackinnon, Alexander C., Oxburgh, Leif, Chu, Gerald C., Sarkar, Molly, Berul, Charles, Smoot, Leslie, Robertson, Elizabeth J., Schwartz, Robert, Seidman, Jonathan G., Seidman, Christine E.
Published 2011

Compensatory metabolic networks in pancreatic cancers upon perturbation of glutamine metabolism

by Biancur, Douglas E., Paulo, Joao A., Małachowska, Beata, Del Rey, Maria Quiles, Sousa, Cristovão M., Wang, Xiaoxu, Sohn, Albert S. W., Chu, Gerald C., Gygi, Steven P., Harper, J. Wade, Fendler, Wojciech, Mancias, Joseph D., Kimmelman, Alec C.
Published in Nat Commun (2017)

Feedback Circuit among INK4 Tumor Suppressors Constrains Human Glioblastoma Development

by Wiedemeyer, Ruprecht, Brennan, Cameron, Heffernan, Timothy P., Xiao, Yonghong, Mahoney, John, Protopopov, Alexei, Zheng, Hongwu, Bignell, Graham, Furnari, Frank, Cavenee, Webster K., Hahn, William C., Ichimura, Koichi, Collins, V. Peter, Chu, Gerald C., Stratton, Michael R., Ligon, Keith L., Futreal, P. Andrew, Chin, Lynda
Published 2008

Oncogenic Kras drives invasion and maintains metastases in colorectal cancer

by Boutin, Adam T., Liao, Wen-Ting, Wang, Melody, Hwang, Soyoon Sarah, Karpinets, Tatiana V., Cheung, Hannah, Chu, Gerald C., Jiang, Shan, Hu, Jian, Chang, Kyle, Vilar, Eduardo, Song, Xingzhi, Zhang, Jianhua, Kopetz, Scott, Futreal, Andrew, Wang, Y. Alan, Kwong, Lawrence N., DePinho, Ronald A.
Published in Genes Dev (2017)

P53 and Pten control neural and glioma stem/progenitor cell renewal and differentiation

by Zheng, Hongwu, Ying, Haoqiang, Yan, Haiyan, Kimmelman, Alec C., Hiller, David J., Chen, An-Jou, Perry, Samuel R., Tonon, Giovanni, Chu, Gerald C., Ding, Zhihu, Stommel, Jayne M., Dunn, Katherine L., Wiedemeyer, Ruprecht, You, Mingjian J., Brennan, Cameron, Wang, Y. Alan, Ligon, Keith L., Wong, Wing H., Chin, Lynda, DePinho, Ronald A.
Published 2008

Pro-invasion metastasis drivers in early stage melanoma are oncogenes

by Scott, Kenneth L., Nogueira, Cristina, Heffernan, Timothy P., van Doorn, Remco, Dhakal, Sabin, Hanna, Jason A., Min, Chengyin, Jaskelioff, Mariela, Xiao, Yonghong, Wu, Chang-Jiun, Cameron, Lisa A., Perry, Samuel R., Zeid, Rhamy, Feinberg, Tamar, Kim, Minjung, Woude, George Vande, Granter, Scott R., Bosenberg, Marcus, Chu, Gerald C., DePinho, Ronald A., Rimm, David L., Chin, Lynda
Published 2011

Genome unstable murine prostate cancers acquire genomic aberrations and bone metastatic features of the human disease

by Ding, Zhihu, Wu, Chang-Jiun, Jaskelioff, Mariela, Ivanova, Elena, Kost-Alimova, Maria, Protopopov, Alexei, Chu, Gerald C., Wang, Guocan, Lu, Xin, Labrot, Emma S., Hu, Jian, Wang, Wei, Xiao, Yonghong, Zhang, Hailei, Zhang, Jianhua, Zhang, Jingfang, Gan, Boyi, Perry, Samuel R., Jiang, Shan, Li, Liren, Horner, James W., Wang, Y. Alan, Chin, Lynda, DePinho, Ronald A.
Published 2012

Genomic alterations link Rho family of GTPases to the highly invasive phenotype of pancreas cancer

by Kimmelman, Alec C., Hezel, Aram F., Aguirre, Andrew J., Zheng, Hongwu, Paik, Ji-hye, Ying, Haoqiang, Chu, Gerald C., Zhang, Jean X., Sahin, Ergun, Yeo, Giminna, Ponugoti, Aditya, Nabioullin, Roustem, Deroo, Scott, Yang, Shenghong, Wang, Xiaoxu, McGrath, John P., Protopopova, Marina, Ivanova, Elena, Zhang, Jianhua, Feng, Bin, Tsao, Ming S., Redston, Mark, Protopopov, Alexei, Xiao, Yonghong, Futreal, P. Andrew, Hahn, William C., Klimstra, David S., Chin, Lynda, DePinho, Ronald A.
Published 2008

Pten is a major tumor suppressor in pancreatic ductal adenocarcinoma and regulates an NF-κB-cytokine network

by Ying, Haoqiang, Elpek, Kutlu G., Vinjamoori, Anant, Zimmerman, Stephanie M., Chu, Gerald C., Yan, Haiyan, Fletcher-Sananikone, Eliot, Zhang, Hailei, Liu, Yingchun, Wang, Wei, Ren, Xiaojia, Zheng, Hongwu, Kimmelman, Alec C., Paik, Ji-hye, Lim, Carol, Perry, Samuel R., Jiang, Shan, Malinn, Brian, Protopopov, Alexei, Colla, Simona, Xiao, Yonghong, Hezel, Aram F., Bardeesy, Nabeel, Turley, Shannon J., Wang, Y. Alan, Chin, Lynda, Thayer, Sarah P., DePinho, Ronald A.
Published 2011