Both p16(Ink4a) and the p19(Arf)-p53 pathway constrain progression of pancreatic adenocarcinoma in the mouse

Activating KRAS mutations and p16(Ink4a) inactivation are near universal events in human pancreatic ductal adenocarcinoma (PDAC). In mouse models, Kras(G12D) initiates formation of premalignant pancreatic ductal lesions, and loss of either Ink4a/Arf (p16(Ink4a)/p19(Arf)) or p53 enables their maligna...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Bardeesy, Nabeel, Aguirre, Andrew J., Chu, Gerald C., Cheng, Kuang-hung, Lopez, Lyle V., Hezel, Aram F., Feng, Bin, Brennan, Cameron, Weissleder, Ralph, Mahmood, Umar, Hanahan, Douglas, Redston, Mark S., Chin, Lynda, DePinho, Ronald A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2006
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1458678/
https://ncbi.nlm.nih.gov/pubmed/16585505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0601273103
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados