p19ARF targets certain E2F species for degradation

p19ARF suppresses the growth of cells lacking p53 through an unknown mechanism. p19ARF was found to complex with transcription factors E2F1, -2, and -3. Levels of endogenous or ectopically expressed E2F1, -2, and -3, but not E2F6, were reduced after synthesis of p19ARF, through a mechanism involving...

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Bibliografiske detaljer
Main Authors: Martelli, Fabio, Hamilton, Timothy, Silver, Daniel P., Sharpless, Norman E., Bardeesy, Nabeel, Rokas, Mihail, DePinho, Ronald A., Livingston, David M., Grossman, Steven R.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2001
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC31856/
https://ncbi.nlm.nih.gov/pubmed/11274364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.081061398
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