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Targeting of C-Terminal Binding Protein (CtBP) by ARF Results in p53-Independent Apoptosis
ARF encodes a potent tumor suppressor that antagonizes MDM2, a negative regulator of p53. ARF also suppresses the proliferation of cells lacking p53, and loss of ARF in p53-null mice, compared with ARF or p53 singly null mice, results in a broadened tumor spectrum and decreased tumor latency. To inv...
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| Hauptverfasser: | , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society for Microbiology
2006
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1430274/ https://ncbi.nlm.nih.gov/pubmed/16508011 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.26.6.2360-2372.2006 |
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