Targeting of C-Terminal Binding Protein (CtBP) by ARF Results in p53-Independent Apoptosis

ARF encodes a potent tumor suppressor that antagonizes MDM2, a negative regulator of p53. ARF also suppresses the proliferation of cells lacking p53, and loss of ARF in p53-null mice, compared with ARF or p53 singly null mice, results in a broadened tumor spectrum and decreased tumor latency. To inv...

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Hlavní autoři: Paliwal, Seema, Pande, Sandhya, Kovi, Ramesh C., Sharpless, Norman E., Bardeesy, Nabeel, Grossman, Steven R.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2006
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1430274/
https://ncbi.nlm.nih.gov/pubmed/16508011
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.26.6.2360-2372.2006
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