Dual Inactivation of RB and p53 Pathways in RAS-Induced Melanomas

The frequent loss of both INK4a and ARF in melanoma raises the question of which INK4a-ARF gene product functions to suppress melanoma genesis in vivo. Moreover, the high incidence of INK4a-ARF inactivation in transformed melanocytes, along with the lack of p53 mutation, implies a cell type-specific...

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Main Authors: Bardeesy, Nabeel, Bastian, Boris C., Hezel, Aram, Pinkel, Dan, DePinho, Ronald A., Chin, Lynda
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2001
Assuntos:
Cell Growth and Development
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC86838/
https://ncbi.nlm.nih.gov/pubmed/11238948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.21.6.2144-2153.2001
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