Cooperative effects of INK4a and ras in melanoma susceptibility in vivo

The familial melanoma gene (INK4a/MTS1/CDKN2) encodes potent tumor suppressor activity. Although mice null for the ink4a homolog develop a cancer-prone condition, a pathogenetic link to melanoma susceptibility has yet to be established. Here we report that mice with melanocyte-specific expression of...

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Bibliografiske detaljer
Main Authors: Chin, Lynda, Pomerantz, Jason, Polsky, David, Jacobson, Mark, Cohen, Carlos, Cordon-Cardo, Carlos, Horner, James W., DePinho, Ronald A.
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 1997
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC316663/
https://ncbi.nlm.nih.gov/pubmed/9353252
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