Cooperative interactions of PTEN deficiency and RAS activation in melanoma metastasis

MAPK and AKT pathways are frequently co-activated in melanoma through overexpression of receptor tyrosine kinases, mutations in their signaling surrogates, such as RAS and BRAF, or loss of negative regulators such as PTEN. Since RAS can be a positive upstream regulator of PI3-K, it has been proposed...

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Detaylı Bibliyografya
Asıl Yazarlar: Nogueira, Cristina, Kim, Kwan-Hyun, Sung, Hyeran, Paraiso, Kim, Dannenberg, Jan-Hermen, Bosenberg, Marcus, Chin, Lynda, Kim, Minjung
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2010
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2989338/
https://ncbi.nlm.nih.gov/pubmed/20711233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2010.349
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