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Cooperative interactions of PTEN deficiency and RAS activation in melanoma metastasis
Melanoma displays frequent activation of RAS/RAF/MAPK and PI3K/AKT signaling pathways as well as inactivation of CDKN2A (INK4a/ARF) and PTEN tumor suppressors via genetic and epigenetic alterations. Pathogenetic roles of these melanoma-prone mutations and their genetic interactions have been establi...
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| Autor principal: | |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Landes Bioscience
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3116600/ https://ncbi.nlm.nih.gov/pubmed/21686270 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/sgtp.1.3.14344 |
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