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Mechanism of RAF isoform switching induced by oncogenic RAS in melanoma

BRAF and RAS are often mutated in cutaneous melanoma and both mutations stimulate the MAPK pathway. However the biological consequences of BRAF and NRAS mutations are different because when RAS is mutated in melanoma, cells use CRAF rather than BRAF to activate MEK/ERK. The mechanism of this BRAF to...

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Detalhes bibliográficos
Autor principal: Dumaz, Nicolas
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3265821/
https://ncbi.nlm.nih.gov/pubmed/22292133
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/sgtp.2.5.17814
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