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Mechanism of RAF isoform switching induced by oncogenic RAS in melanoma
BRAF and RAS are often mutated in cutaneous melanoma and both mutations stimulate the MAPK pathway. However the biological consequences of BRAF and NRAS mutations are different because when RAS is mutated in melanoma, cells use CRAF rather than BRAF to activate MEK/ERK. The mechanism of this BRAF to...
Bewaard in:
| Hoofdauteur: | |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
Landes Bioscience
2011
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3265821/ https://ncbi.nlm.nih.gov/pubmed/22292133 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/sgtp.2.5.17814 |
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