Circular ANRIL isoforms switch from repressors to activators of p15/CDKN2B expression during RAF1 oncogene-induced senescence

Long non-coding RNAs (ncRNAs) are major regulators of gene expression and cell fate. The INK4 locus encodes the tumour suppressor proteins p15(INK4b), p16(INK4a) and p14(ARF) required for cell cycle arrest and whose expression increases during senescence. ANRIL is a ncRNA antisense to the p15 gene....

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Detalhes bibliográficos
Publicado no:RNA Biol
Main Authors: Muniz, Lisa, Lazorthes, Sandra, Delmas, Maxime, Ouvrard, Julien, Aguirrebengoa, Marion, Trouche, Didier, Nicolas, Estelle
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2020
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Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7951966/
https://ncbi.nlm.nih.gov/pubmed/32862732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15476286.2020.1812910
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