Circular ANRIL isoforms switch from repressors to activators of p15/CDKN2B expression during RAF1 oncogene-induced senescence

Long non-coding RNAs (ncRNAs) are major regulators of gene expression and cell fate. The INK4 locus encodes the tumour suppressor proteins p15(INK4b), p16(INK4a) and p14(ARF) required for cell cycle arrest and whose expression increases during senescence. ANRIL is a ncRNA antisense to the p15 gene....

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:RNA Biol
Prif Awduron: Muniz, Lisa, Lazorthes, Sandra, Delmas, Maxime, Ouvrard, Julien, Aguirrebengoa, Marion, Trouche, Didier, Nicolas, Estelle
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Taylor & Francis 2020
Pynciau:
Research Paper
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7951966/
https://ncbi.nlm.nih.gov/pubmed/32862732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15476286.2020.1812910
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