Circular ANRIL isoforms switch from repressors to activators of p15/CDKN2B expression during RAF1 oncogene-induced senescence

Long non-coding RNAs (ncRNAs) are major regulators of gene expression and cell fate. The INK4 locus encodes the tumour suppressor proteins p15(INK4b), p16(INK4a) and p14(ARF) required for cell cycle arrest and whose expression increases during senescence. ANRIL is a ncRNA antisense to the p15 gene....

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Detalles Bibliográficos
Publicado en:RNA Biol
Main Authors: Muniz, Lisa, Lazorthes, Sandra, Delmas, Maxime, Ouvrard, Julien, Aguirrebengoa, Marion, Trouche, Didier, Nicolas, Estelle
Formato: Artigo
Idioma:Inglês
Publicado: Taylor & Francis 2020
Assuntos:
Research Paper
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7951966/
https://ncbi.nlm.nih.gov/pubmed/32862732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15476286.2020.1812910
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