A vlincRNA participates in senescence maintenance by relieving H2AZ-mediated repression at the INK4 locus

Non-coding RNAs (ncRNAs) play major roles in proper chromatin organization and function. Senescence, a strong anti-proliferative process and a major anticancer barrier, is associated with dramatic chromatin reorganization in heterochromatin foci. Here we analyze strand-specific transcriptome changes...

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Pubblicato in:Nat Commun
Autori principali: Lazorthes, Sandra, Vallot, Céline, Briois, Sébastien, Aguirrebengoa, Marion, Thuret, Jean-Yves, Laurent, Georges St., Rougeulle, Claire, Kapranov, Philipp, Mann, Carl, Trouche, Didier, Nicolas, Estelle
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Pub. Group 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4309439/
https://ncbi.nlm.nih.gov/pubmed/25601475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms6971
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