β-Catenin induces immortalization of melanocytes by suppressing p16(INK4a) expression and cooperates with N-Ras in melanoma development

Tumor progression is a multistep process in which proproliferation mutations must be accompanied by suppression of senescence. In melanoma, proproliferative signals are provided by activating mutations in NRAS and BRAF, whereas senescence is bypassed by inactivation of the p16(Ink4a) gene. Melanomas...

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Kaydedildi:
Detaylı Bibliyografya
Asıl Yazarlar: Delmas, Véronique, Beermann, Friedrich, Martinozzi, Silvia, Carreira, Suzanne, Ackermann, Julien, Kumasaka, Mayuko, Denat, Laurence, Goodall, Jane, Luciani, Flavie, Viros, Amaya, Demirkan, Nese, Bastian, Boris C., Goding, Colin R., Larue, Lionel
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Cold Spring Harbor Laboratory Press 2007
Konular:
Research Paper
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2049194/
https://ncbi.nlm.nih.gov/pubmed/18006687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.450107
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