β-Catenin induces immortalization of melanocytes by suppressing p16(INK4a) expression and cooperates with N-Ras in melanoma development

Tumor progression is a multistep process in which proproliferation mutations must be accompanied by suppression of senescence. In melanoma, proproliferative signals are provided by activating mutations in NRAS and BRAF, whereas senescence is bypassed by inactivation of the p16(Ink4a) gene. Melanomas...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Delmas, Véronique, Beermann, Friedrich, Martinozzi, Silvia, Carreira, Suzanne, Ackermann, Julien, Kumasaka, Mayuko, Denat, Laurence, Goodall, Jane, Luciani, Flavie, Viros, Amaya, Demirkan, Nese, Bastian, Boris C., Goding, Colin R., Larue, Lionel
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Cold Spring Harbor Laboratory Press 2007
Aiheet:
Research Paper
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2049194/
https://ncbi.nlm.nih.gov/pubmed/18006687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.450107
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