β-Catenin induces immortalization of melanocytes by suppressing p16(INK4a) expression and cooperates with N-Ras in melanoma development

Tumor progression is a multistep process in which proproliferation mutations must be accompanied by suppression of senescence. In melanoma, proproliferative signals are provided by activating mutations in NRAS and BRAF, whereas senescence is bypassed by inactivation of the p16(Ink4a) gene. Melanomas...

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Detalhes bibliográficos
Main Authors: Delmas, Véronique, Beermann, Friedrich, Martinozzi, Silvia, Carreira, Suzanne, Ackermann, Julien, Kumasaka, Mayuko, Denat, Laurence, Goodall, Jane, Luciani, Flavie, Viros, Amaya, Demirkan, Nese, Bastian, Boris C., Goding, Colin R., Larue, Lionel
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2007
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2049194/
https://ncbi.nlm.nih.gov/pubmed/18006687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.450107
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