β-Catenin induces immortalization of melanocytes by suppressing p16(INK4a) expression and cooperates with N-Ras in melanoma development

Tumor progression is a multistep process in which proproliferation mutations must be accompanied by suppression of senescence. In melanoma, proproliferative signals are provided by activating mutations in NRAS and BRAF, whereas senescence is bypassed by inactivation of the p16(Ink4a) gene. Melanomas...

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Main Authors: Delmas, Véronique, Beermann, Friedrich, Martinozzi, Silvia, Carreira, Suzanne, Ackermann, Julien, Kumasaka, Mayuko, Denat, Laurence, Goodall, Jane, Luciani, Flavie, Viros, Amaya, Demirkan, Nese, Bastian, Boris C., Goding, Colin R., Larue, Lionel
格式: Artigo
語言:Inglês
出版: Cold Spring Harbor Laboratory Press 2007
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Research Paper
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2049194/
https://ncbi.nlm.nih.gov/pubmed/18006687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.450107
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