Hyperactivation of Ha-ras oncogene, but not Ink4a/Arf deficiency, triggers bladder tumorigenesis

Although ras is a potent mitogenic oncogene, its tumorigenicity depends on cellular context and cooperative events. Here we show that low-level expression of a constitutively active Ha-ras in mouse urothelium induces simple urothelial hyperplasia that is resistant to progression to full-fledged blad...

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Bibliographic Details
Main Authors: Mo, Lan, Zheng, Xiaoyong, Huang, Hong-Ying, Shapiro, Ellen, Lepor, Herbert, Cordon-Cardo, Carlos, Sun, Tung-Tien, Wu, Xue-Ru
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2007
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1770948/
https://ncbi.nlm.nih.gov/pubmed/17256055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI30062
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