Cooperativity of Oncogenic K-Ras and Downregulated p16/INK4A in Human Pancreatic Tumorigenesis

Activation of K-ras and inactivation of p16 are the most frequently identified genetic alterations in human pancreatic epithelial adenocarcinoma (PDAC). Mouse models engineered with mutant K-ras and deleted p16 recapitulate key pathological features of PDAC. However, a human cell culture transformat...

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Bibliografiske detaljer
Main Authors: Chang, Zhe, Ju, Huaiqiang, Ling, Jianhua, Zhuang, Zhuonan, Li, Zhongkui, Wang, Huamin, Fleming, Jason B., Freeman, James W., Yu, Dihua, Huang, Peng, Chiao, Paul J.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2014
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4100754/
https://ncbi.nlm.nih.gov/pubmed/25029561
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0101452
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