Histone demethylase JMJD3 contributes to epigenetic control of INK4a/ARF by oncogenic RAS

The INK4a/ARF tumor suppressor locus, a key executor of cellular senescence, is regulated by members of the Polycomb group (PcG) of transcriptional repressors. Here we show that signaling from oncogenic RAS overrides PcG-mediated repression of INK4a by activating the H3K27 demethylase JMJD3 and down...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Barradas, Marta, Anderton, Emma, Acosta, Juan Carlos, Li, SiDe, Banito, Ana, Rodriguez-Niedenführ, Marc, Maertens, Goedele, Banck, Michaela, Zhou, Ming-Ming, Walsh, Martin J., Peters, Gordon, Gil, Jesús
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Cold Spring Harbor Laboratory Press 2009
Pynciau:
Research Communication
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2685533/
https://ncbi.nlm.nih.gov/pubmed/19451218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.511109
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg