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EGFR/ARF6 regulation of Hh signalling stimulates oncogenic Ras tumour overgrowth

Multiple signalling events interact in cancer cells. Oncogenic Ras cooperates with Egfr, which cannot be explained by the canonical signalling paradigm. In turn, Egfr cooperates with Hedgehog signalling. How oncogenic Ras elicits and integrates Egfr and Hedgehog signals to drive overgrowth remains u...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Chabu, Chiswili, Li, Da-Ming, Xu, Tian
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5353614/
https://ncbi.nlm.nih.gov/pubmed/28281543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms14688
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