ARF6 is an actionable node that orchestrates oncogenic GNAQ signaling in uveal melanoma

Activating mutations in Gαq proteins, which form the a subunit of certain heterotrimeric G proteins, drive uveal melanoma oncogenesis by triggering multiple downstream signaling pathways, including PLC/PKC, Rho/Rac, and YAP. Here we show that the small GTPase ARF6 acts as a proximal node of oncogeni...

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Bibliographic Details
Published in:Cancer Cell
Main Authors: Yoo, Jae Hyuk, Shi, Dallas S., Grossmann, Allie H., Sorensen, Lise K., Tong, ZongZhong, Mleynek, Tara M., Rogers, Aaron, Zhu, Weiquan, Richards, Jackson R., Winter, Jacob M., Zhu, Jie, Dunn, Christine, Bajji, Ashok, Shenderovich, Mark, Mueller, Alan L., Woodman, Scott E., Harbour, J. William, Thomas, Kirk R., Odelberg, Shannon J., Ostanin, Kirill, Li, Dean Y.
Format: Artigo
Language:Inglês
Published: 2016
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5027844/
https://ncbi.nlm.nih.gov/pubmed/27265506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2016.04.015
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