ARF6 is an actionable node that orchestrates oncogenic GNAQ signaling in uveal melanoma

Activating mutations in Gαq proteins, which form the a subunit of certain heterotrimeric G proteins, drive uveal melanoma oncogenesis by triggering multiple downstream signaling pathways, including PLC/PKC, Rho/Rac, and YAP. Here we show that the small GTPase ARF6 acts as a proximal node of oncogeni...

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Publicat a:Cancer Cell
Autors principals: Yoo, Jae Hyuk, Shi, Dallas S., Grossmann, Allie H., Sorensen, Lise K., Tong, ZongZhong, Mleynek, Tara M., Rogers, Aaron, Zhu, Weiquan, Richards, Jackson R., Winter, Jacob M., Zhu, Jie, Dunn, Christine, Bajji, Ashok, Shenderovich, Mark, Mueller, Alan L., Woodman, Scott E., Harbour, J. William, Thomas, Kirk R., Odelberg, Shannon J., Ostanin, Kirill, Li, Dean Y.
Format: Artigo
Idioma:Inglês
Publicat: 2016
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5027844/
https://ncbi.nlm.nih.gov/pubmed/27265506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2016.04.015
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