ARF6 is an actionable node that orchestrates oncogenic GNAQ signaling in uveal melanoma

Activating mutations in Gαq proteins, which form the a subunit of certain heterotrimeric G proteins, drive uveal melanoma oncogenesis by triggering multiple downstream signaling pathways, including PLC/PKC, Rho/Rac, and YAP. Here we show that the small GTPase ARF6 acts as a proximal node of oncogeni...

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Vydáno v:Cancer Cell
Hlavní autoři: Yoo, Jae Hyuk, Shi, Dallas S., Grossmann, Allie H., Sorensen, Lise K., Tong, ZongZhong, Mleynek, Tara M., Rogers, Aaron, Zhu, Weiquan, Richards, Jackson R., Winter, Jacob M., Zhu, Jie, Dunn, Christine, Bajji, Ashok, Shenderovich, Mark, Mueller, Alan L., Woodman, Scott E., Harbour, J. William, Thomas, Kirk R., Odelberg, Shannon J., Ostanin, Kirill, Li, Dean Y.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5027844/
https://ncbi.nlm.nih.gov/pubmed/27265506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2016.04.015
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