Histone demethylase JMJD3 contributes to epigenetic control of INK4a/ARF by oncogenic RAS

The INK4a/ARF tumor suppressor locus, a key executor of cellular senescence, is regulated by members of the Polycomb group (PcG) of transcriptional repressors. Here we show that signaling from oncogenic RAS overrides PcG-mediated repression of INK4a by activating the H3K27 demethylase JMJD3 and down...

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Hlavní autoři: Barradas, Marta, Anderton, Emma, Acosta, Juan Carlos, Li, SiDe, Banito, Ana, Rodriguez-Niedenführ, Marc, Maertens, Goedele, Banck, Michaela, Zhou, Ming-Ming, Walsh, Martin J., Peters, Gordon, Gil, Jesús
Médium: Artigo
Jazyk:Inglês
Vydáno: Cold Spring Harbor Laboratory Press 2009
Témata:
Research Communication
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2685533/
https://ncbi.nlm.nih.gov/pubmed/19451218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.511109
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