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MSK1 triggers the expression of the INK4AB/ARF locus in oncogene-induced senescence
The tumor suppressor proteins p15(INK4B), p16(INK4A), and p14(ARF), encoded by the INK4AB/ARF locus, are crucial regulators of cellular senescence. The locus is epigenetically silenced by the repressive Polycomb complexes in growing cells but is activated in response to oncogenic stress. Here we sho...
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| 出版年: | Mol Biol Cell |
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| 主要な著者: | , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
The American Society for Cell Biology
2016
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5007092/ https://ncbi.nlm.nih.gov/pubmed/27385346 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E15-11-0772 |
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