Loading...

Ink4-Arf Locus in Cancer and Aging

Three tumor suppressor genes at the small (<50 kb) INK4-ARF (CDKN2A/B) locus on human chromosome 9p21 coordinate a signalling network that depends on the activities of the retinoblastoma protein (RB) and the p53 transcription factor. Disruption of this circuitry, frequently by co-deletion of INK4...

Full description

Saved in:
Bibliographic Details
Main Author: Sherr, Charles J.
Format: Artigo
Language:Inglês
Published: 2012
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3434949/
https://ncbi.nlm.nih.gov/pubmed/22960768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/wdev.40
Tags: Add Tag
No Tags, Be the first to tag this record!