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Ink4-Arf Locus in Cancer and Aging
Three tumor suppressor genes at the small (<50 kb) INK4-ARF (CDKN2A/B) locus on human chromosome 9p21 coordinate a signalling network that depends on the activities of the retinoblastoma protein (RB) and the p53 transcription factor. Disruption of this circuitry, frequently by co-deletion of INK4...
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3434949/ https://ncbi.nlm.nih.gov/pubmed/22960768 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/wdev.40 |
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