Alterations in RD(INK4/ARF)-mediated en bloc regulation of the INK4-ARF locus in human squamous cell carcinoma of the head and neck

The presence of RD(INK4)(/)(ARF) (RD) enhancer in the INK4-ARF locus provides a novel mechanism to simultaneously increase the transcription of p15(INK4b) (p15), p14ARF (p14), and p16(INK4a) (p16). While such up-regulation can be repressed through interactions between RD and oncoproteins CDC6 and BM...

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Main Authors: Poi, Ming J., Knobloch, Thomas J., Sears, Marta T., Warner, Blake M., Uhrig, Lana K., Weghorst, Christopher M., Li, Junan
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4102663/
https://ncbi.nlm.nih.gov/pubmed/24302590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/mc.22119
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