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Alterations in RD(INK4/ARF)-mediated en bloc regulation of the INK4-ARF locus in human squamous cell carcinoma of the head and neck
The presence of RD(INK4)(/)(ARF) (RD) enhancer in the INK4-ARF locus provides a novel mechanism to simultaneously increase the transcription of p15(INK4b) (p15), p14ARF (p14), and p16(INK4a) (p16). While such up-regulation can be repressed through interactions between RD and oncoproteins CDC6 and BM...
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| Autores principales: | , , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2013
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4102663/ https://ncbi.nlm.nih.gov/pubmed/24302590 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/mc.22119 |
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