Transcription factor genes Smad4 and Gata4 cooperatively regulate cardiac valve development

We report that the dominant human missense mutations G303E and G296S in GATA4, a cardiac-specific transcription factor gene, cause atrioventricular septal defects and valve abnormalities by disrupting a signaling cascade involved in endocardial cushion development. These GATA4 missense mutations, bu...

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Detalhes bibliográficos
Main Authors: Moskowitz, Ivan P., Wang, Jun, Peterson, Michael A., Pu, William T., Mackinnon, Alexander C., Oxburgh, Leif, Chu, Gerald C., Sarkar, Molly, Berul, Charles, Smoot, Leslie, Robertson, Elizabeth J., Schwartz, Robert, Seidman, Jonathan G., Seidman, Christine E.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2011
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3053967/
https://ncbi.nlm.nih.gov/pubmed/21330551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1019025108
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