Compensatory metabolic networks in pancreatic cancers upon perturbation of glutamine metabolism

Pancreatic ductal adenocarcinoma is a notoriously difficult-to-treat cancer and patients are in need of novel therapies. We have shown previously that these tumours have altered metabolic requirements, making them highly reliant on a number of adaptations including a non-canonical glutamine (Gln) me...

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Pubblicato in:Nat Commun
Autori principali: Biancur, Douglas E., Paulo, Joao A., Małachowska, Beata, Del Rey, Maria Quiles, Sousa, Cristovão M., Wang, Xiaoxu, Sohn, Albert S. W., Chu, Gerald C., Gygi, Steven P., Harper, J. Wade, Fendler, Wojciech, Mancias, Joseph D., Kimmelman, Alec C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5500878/
https://ncbi.nlm.nih.gov/pubmed/28671190
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms15965
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