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Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy

Autophagy, the process by which proteins and organelles are sequestered in double-membrane structures called autophagosomes and delivered to lysosomes for degradation, is critical in diseases such as cancer and neurodegeneration(1,2). Much of our understanding of this process has emerged from analys...

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Hlavní autoři: Mancias, Joseph D., Wang, Xiaoxu, Gygi, Steven P., Harper, J. Wade, Kimmelman, Alec C.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4180099/
https://ncbi.nlm.nih.gov/pubmed/24695223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature13148
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