XBP-1 is required for biogenesis of cellular secretory machinery of exocrine glands

Por Lee, Ann-Hwee, Chu, Gerald C, Iwakoshi, Neal N, Glimcher, Laurie H
Publicado em 2005

Imaging guided trials of the angiogenesis inhibitor sunitinib in mouse models predict efficacy in pancreatic neuroendocrine but not ductal carcinoma

Por Olson, Peter, Chu, Gerald C., Perry, Samuel R., Nolan-Stevaux, Olivier, Hanahan, Douglas
Publicado em 2011

Specific requirement of the chromatin modifier mSin3B in cell cycle exit and cellular differentiation

Por David, Gregory, Grandinetti, Kathryn B., Finnerty, Patricia M., Simpson, Natalie, Chu, Gerald C., DePinho, Ronald A.
Publicado em 2008

GLI1 is regulated through Smoothened-independent mechanisms in neoplastic pancreatic ducts and mediates PDAC cell survival and transformation

Por Nolan-Stevaux, Olivier, Lau, Janet, Truitt, Morgan L., Chu, Gerald C., Hebrok, Matthias, Fernández-Zapico, Martin E., Hanahan, Douglas
Publicado em 2009

Ott1 (Rbm15) Is Essential for Placental Vascular Branching Morphogenesis and Embryonic Development of the Heart and Spleen

Por Raffel, Glen D., Chu, Gerald C., Jesneck, Jonathan L., Cullen, Dana E., Bronson, Roderick T., Bernard, Olivier A., Gilliland, D. Gary
Publicado em 2009

Context-Dependent Transformation of Adult Pancreatic Cells by Oncogenic K-Ras

Por Gidekel Friedlander, Sharon Y, Chu, Gerald C., Snyder, Eric L., Girnius, Nomeda, Dibelius, Gregory, Crowley, Denise, Vasile, Eliza, DePinho, Ronald A., Jacks, Tyler
Publicado em 2009

Autophagy is critical for pancreatic tumor growth and progression in tumors with p53 alterations

Por Yang, Annan, Rajeshkumar, N.V., Wang, Xiaoxu, Yabuuchi, Shinichi, Alexander, Brian M., Chu, Gerald C., Von Hoff, Daniel D., Maitra, Anirban, Kimmelman, Alec C.
Publicado em 2014

Smad4 is dispensable for normal pancreas development yet critical in progression and tumor biology of pancreas cancer

Por Bardeesy, Nabeel, Cheng, Kuang-hung, Berger, Justin H., Chu, Gerald C., Pahler, Jessica, Olson, Peter, Hezel, Aram F., Horner, James, Lauwers, Gregory Y., Hanahan, Douglas, DePinho, Ronald A.
Publicado em 2006

Mutant N-Ras protects colorectal cancer cells from stress-induced apoptosis and contributes to cancer development and progression

Por Wang, Yufang, Velho, Sérgia, Vakiani, Efsevia, Peng, Shouyong, Bass, Adam J., Chu, Gerald C., Gierut, Jessica, Bugni, James M., Der, Channing J., Philips, Mark, Solit, David B., Haigis, Kevin M.
Publicado em 2012

Animal models of human prostate cancer: The Consensus Report of the New York Meeting of the Mouse Models of Human Cancers Consortium Prostate Pathology Committee

Por Ittmann, Michael, Huang, Jiaoti, Radaelli, Enrico, Martin, Philip, Signoretti, Sabina, Sullivan, Ruth, Simons, Brian W., Ward, Jerrold M., Robinson, Brian D., Chu, Gerald C., Loda, Massimo, Thomas, George, Borowsky, Alexander, Cardiff, Robert D.
Publicado em 2013

Both p16(Ink4a) and the p19(Arf)-p53 pathway constrain progression of pancreatic adenocarcinoma in the mouse

Por Bardeesy, Nabeel, Aguirre, Andrew J., Chu, Gerald C., Cheng, Kuang-hung, Lopez, Lyle V., Hezel, Aram F., Feng, Bin, Brennan, Cameron, Weissleder, Ralph, Mahmood, Umar, Hanahan, Douglas, Redston, Mark S., Chin, Lynda, DePinho, Ronald A.
Publicado em 2006

Transcription factor genes Smad4 and Gata4 cooperatively regulate cardiac valve development

Por Moskowitz, Ivan P., Wang, Jun, Peterson, Michael A., Pu, William T., Mackinnon, Alexander C., Oxburgh, Leif, Chu, Gerald C., Sarkar, Molly, Berul, Charles, Smoot, Leslie, Robertson, Elizabeth J., Schwartz, Robert, Seidman, Jonathan G., Seidman, Christine E.
Publicado em 2011

Compensatory metabolic networks in pancreatic cancers upon perturbation of glutamine metabolism

Por Biancur, Douglas E., Paulo, Joao A., Małachowska, Beata, Del Rey, Maria Quiles, Sousa, Cristovão M., Wang, Xiaoxu, Sohn, Albert S. W., Chu, Gerald C., Gygi, Steven P., Harper, J. Wade, Fendler, Wojciech, Mancias, Joseph D., Kimmelman, Alec C.
Publicado no Nat Commun (2017)

Feedback Circuit among INK4 Tumor Suppressors Constrains Human Glioblastoma Development

Por Wiedemeyer, Ruprecht, Brennan, Cameron, Heffernan, Timothy P., Xiao, Yonghong, Mahoney, John, Protopopov, Alexei, Zheng, Hongwu, Bignell, Graham, Furnari, Frank, Cavenee, Webster K., Hahn, William C., Ichimura, Koichi, Collins, V. Peter, Chu, Gerald C., Stratton, Michael R., Ligon, Keith L., Futreal, P. Andrew, Chin, Lynda
Publicado em 2008

Oncogenic Kras drives invasion and maintains metastases in colorectal cancer

Por Boutin, Adam T., Liao, Wen-Ting, Wang, Melody, Hwang, Soyoon Sarah, Karpinets, Tatiana V., Cheung, Hannah, Chu, Gerald C., Jiang, Shan, Hu, Jian, Chang, Kyle, Vilar, Eduardo, Song, Xingzhi, Zhang, Jianhua, Kopetz, Scott, Futreal, Andrew, Wang, Y. Alan, Kwong, Lawrence N., DePinho, Ronald A.
Publicado no Genes Dev (2017)

P53 and Pten control neural and glioma stem/progenitor cell renewal and differentiation

Por Zheng, Hongwu, Ying, Haoqiang, Yan, Haiyan, Kimmelman, Alec C., Hiller, David J., Chen, An-Jou, Perry, Samuel R., Tonon, Giovanni, Chu, Gerald C., Ding, Zhihu, Stommel, Jayne M., Dunn, Katherine L., Wiedemeyer, Ruprecht, You, Mingjian J., Brennan, Cameron, Wang, Y. Alan, Ligon, Keith L., Wong, Wing H., Chin, Lynda, DePinho, Ronald A.
Publicado em 2008

Pro-invasion metastasis drivers in early stage melanoma are oncogenes

Por Scott, Kenneth L., Nogueira, Cristina, Heffernan, Timothy P., van Doorn, Remco, Dhakal, Sabin, Hanna, Jason A., Min, Chengyin, Jaskelioff, Mariela, Xiao, Yonghong, Wu, Chang-Jiun, Cameron, Lisa A., Perry, Samuel R., Zeid, Rhamy, Feinberg, Tamar, Kim, Minjung, Woude, George Vande, Granter, Scott R., Bosenberg, Marcus, Chu, Gerald C., DePinho, Ronald A., Rimm, David L., Chin, Lynda
Publicado em 2011

Genome unstable murine prostate cancers acquire genomic aberrations and bone metastatic features of the human disease

Por Ding, Zhihu, Wu, Chang-Jiun, Jaskelioff, Mariela, Ivanova, Elena, Kost-Alimova, Maria, Protopopov, Alexei, Chu, Gerald C., Wang, Guocan, Lu, Xin, Labrot, Emma S., Hu, Jian, Wang, Wei, Xiao, Yonghong, Zhang, Hailei, Zhang, Jianhua, Zhang, Jingfang, Gan, Boyi, Perry, Samuel R., Jiang, Shan, Li, Liren, Horner, James W., Wang, Y. Alan, Chin, Lynda, DePinho, Ronald A.
Publicado em 2012

Genomic alterations link Rho family of GTPases to the highly invasive phenotype of pancreas cancer

Por Kimmelman, Alec C., Hezel, Aram F., Aguirre, Andrew J., Zheng, Hongwu, Paik, Ji-hye, Ying, Haoqiang, Chu, Gerald C., Zhang, Jean X., Sahin, Ergun, Yeo, Giminna, Ponugoti, Aditya, Nabioullin, Roustem, Deroo, Scott, Yang, Shenghong, Wang, Xiaoxu, McGrath, John P., Protopopova, Marina, Ivanova, Elena, Zhang, Jianhua, Feng, Bin, Tsao, Ming S., Redston, Mark, Protopopov, Alexei, Xiao, Yonghong, Futreal, P. Andrew, Hahn, William C., Klimstra, David S., Chin, Lynda, DePinho, Ronald A.
Publicado em 2008

Pten is a major tumor suppressor in pancreatic ductal adenocarcinoma and regulates an NF-κB-cytokine network

Por Ying, Haoqiang, Elpek, Kutlu G., Vinjamoori, Anant, Zimmerman, Stephanie M., Chu, Gerald C., Yan, Haiyan, Fletcher-Sananikone, Eliot, Zhang, Hailei, Liu, Yingchun, Wang, Wei, Ren, Xiaojia, Zheng, Hongwu, Kimmelman, Alec C., Paik, Ji-hye, Lim, Carol, Perry, Samuel R., Jiang, Shan, Malinn, Brian, Protopopov, Alexei, Colla, Simona, Xiao, Yonghong, Hezel, Aram F., Bardeesy, Nabeel, Turley, Shannon J., Wang, Y. Alan, Chin, Lynda, Thayer, Sarah P., DePinho, Ronald A.
Publicado em 2011