GLI1 is regulated through Smoothened-independent mechanisms in neoplastic pancreatic ducts and mediates PDAC cell survival and transformation

Pancreatic ductal adenocarcinoma (PDAC) is characterized by the deregulation of the hedgehog signaling pathway. The Sonic Hedgehog ligand (Shh), absent in the normal pancreas, is highly expressed in pancreatic tumors and is sufficient to induce neoplastic precursor lesions in mouse models. We invest...

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Detalhes bibliográficos
Main Authors: Nolan-Stevaux, Olivier, Lau, Janet, Truitt, Morgan L., Chu, Gerald C., Hebrok, Matthias, Fernández-Zapico, Martin E., Hanahan, Douglas
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2009
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2632164/
https://ncbi.nlm.nih.gov/pubmed/19136624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1753809
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