Synthesis and Biological Evaluation of Cremastrine and an Unnatural Analogue

Por Hahn, Kristopher N., Fadeyi, Olugbeminiyi O., Cho, Hyekyung P., Lindsley, Craig W.
Publicado em 2012

The Dual-Specificity Phosphatase CDC14B Bundles and Stabilizes Microtubules

Por Cho, Hyekyung P., Liu, Yie, Gomez, Marla, Dunlap, John, Tyers, Mike, Wang, Yisong
Publicado em 2005

Cdc14B depletion leads to centriole amplification, and its overexpression prevents unscheduled centriole duplication

Por Wu, Jun, Cho, Hyekyung P., Rhee, David B., Johnson, Dabney K., Dunlap, John, Liu, Yie, Wang, Yisong
Publicado em 2008

Lead optimization of the VU0486321 series of mGlu(1) PAMs. Part 1. SAR of modifications to the central aryl core

Por Garcia-Barrantes, Pedro M., Cho, Hyekyung P., Blobaum, Anna L., Niswender, Colleen M., Conn, P. Jeffrey, Lindsley, Craig W.
Publicado no Bioorg Med Chem Lett (2015)

Lead optimization of the VU0486321 series of mGlu(1) PAMs. Part 3. Engineering plasma stability by discovery and optimization of isoindolinone analogs

Por Garcia-Barrantes, Pedro M., Cho, Hyekyung P., Blobaum, Anna L., Niswender, Colleen M., Conn, P. Jeffrey, Lindsley, Craig W.
Publicado no Bioorg Med Chem Lett (2016)

Lead optimization of the VU0486321 series of mGlu(1) PAMs. Part 2. SAR of alternative 3-methyl heterocycles and progress towards an in vivo tool

Por Garcia-Barrantes, Pedro M., Cho, Hyekyung P., Metts, Adam M., Blobaum, Anna L., Niswender, Colleen M., Conn, P. Jeffrey, Lindsley, Craig W.
Publicado no Bioorg Med Chem Lett (2016)

Re-exploration of the mGlu(1) PAM Ro 07-11401 scaffold: Discovery of analogs with improved CNS penetration despite steep SAR

Por Garcia-Barrantes, Pedro M., Cho, Hyekyung P., Starr, Tahj M., Blobaum, Anna L., Niswender, Colleen M., Conn, P. Jeffrey, Lindsley, Craig W.
Publicado no Bioorg Med Chem Lett (2016)

Phospholipase D1 is required for angiogenesis of intersegmental blood vessels in zebrafish

Por Zeng, Xin-Xin I., Zheng, Xiangjian, Xiang, Yun, Cho, Hyekyung P., Jessen, Jason R., Zhong, Tao P., Solnica-Krezel, Lilianna, Brown, H. Alex
Publicado em 2009

Chemical Lead Optimization of a pan G(q) mAChR M(1), M(3), M(5) Positive Allosteric Modulator (PAM) Lead. Part I. Development of the first highly selective M(5) PAM

Por Bridges, Thomas M., Kennedy, J. Phillip, Cho, Hyekyung P., Breininger, Micah L., Gentry, Patrick R., Hopkins, Corey R., Conn, P. Jeffrey, Lindsley, Craig W.
Publicado em 2009

A Novel Class of Succinimide-Derived Negative Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 1 Provides Insight into a Disconnect in Activity between the Rat and...

Por Cho, Hyekyung P., Engers, Darren W., Venable, Daryl F., Niswender, Colleen M., Lindsley, Craig W., Conn, P. Jeffrey, Emmitte, Kyle A., Rodriguez, Alice L.
Publicado em 2014

Synthesis and evaluation of 4,6-disubstituted pyrimidines as CNS penetrant pan-muscarinic antagonists with a novel chemotype

Por Bender, Aaron M., Weiner, Rebecca L., Luscombe, Vincent B., Cho, Hyekyung P., Niswender, Colleen M., Engers, Darren W., Bridges, Thomas M., Conn, P. Jeffrey, Lindsley, Craig W.
Publicado no Bioorg Med Chem Lett (2017)

Regulation of Phospholipase D Activity and Phosphatidic Acid Production after Purinergic (P2Y(6)) Receptor Stimulation

Por Scott, Sarah A., Xiang, Yun, Mathews, Thomas P., Cho, Hyekyung P., Myers, David S., Armstrong, Michelle D., Tallman, Keri A., O'Reilly, Matthew C., Lindsley, Craig W., Brown, H. Alex
Publicado em 2013

Design of isoform-selective phospholipase D inhibitors that modulate cancer cell invasiveness

Por Scott, Sarah A, Selvy, Paige E, Buck, Jason R, Cho, Hyekyung P, Criswell, Tracy L, Thomas, Ashley L, Armstrong, Michelle D, Arteaga, Carlos L, Lindsley, Craig W, Brown, H Alex
Publicado em 2009

Structure of a class C GPCR metabotropic glutamate receptor 1 bound to an allosteric modulator()

Por Wu, Huixian, Wang, Chong, Gregory, Karen J., Han, Gye Won, Cho, Hyekyung P., Xia, Yan, Niswender, Colleen M., Katritch, Vsevolod, Meiler, Jens, Cherezov, Vadim, Conn, P. Jeffrey, Stevens, Raymond C.
Publicado em 2014

Development of Novel, CNS Penetrant Positive Allosteric Modulators for the Metabotropic Glutamate Receptor Subtype 1 (mGlu(1)), Based on an N-(3-Chloro-4-(1,3-dioxoisoindolin-2-yl)...

Por Garcia-Barrantes, Pedro M., Cho, Hyekyung P., Niswender, Colleen M., Byers, Frank W., Locuson, Charles W., Blobaum, Anna L., Xiang, Zixiu, Rook, Jerri M., Conn, P. Jeffrey, Lindsley, Craig W.
Publicado no J Med Chem (2015)

Further optimization of the M(5) NAM MLPCN probe ML375: Tactics and challenges

Por Kurata, Haruto, Gentry, Patrick R., Kokubo, Masaya, Cho, Hyekyung P., Bridges, Thomas M., Niswender, Colleen M., Byers, Frank W., Wood, Michael R., Daniels, J. Scott, Conn, P. Jeffrey, Lindsley, Craig W.
Publicado no Bioorg Med Chem Lett (2014)

Octahydropyrrolo[3,4-c]pyrrole negative allosteric modulators of mGlu(1)

Por Manka, Jason T., Rodriguez, Alice L., Morrison, Ryan D., Venable, Daryl F., Cho, Hyekyung P., Blobaum, Anna L., Daniels, J. Scott, Niswender, Colleen M., Conn, P. Jeffrey, Lindsley, Craig W., Emmitte, Kyle A.
Publicado em 2013

N-Acyl-N′-arylpiperazines as negative allosteric modulators of mGlu(1): Identification of VU0469650, a potent and selective tool compound with CNS exposure in rats

Por Lovell, Kimberly M., Felts, Andrew S., Rodriguez, Alice L., Venable, Daryl F., Cho, Hyekyung P., Morrison, Ryan D., Byers, Frank W., Daniels, J. Scott, Niswender, Colleen M., Conn, P. Jeffrey, Lindsley, Craig W., Emmitte, Kyle A.
Publicado em 2013

Further exploration of M(1) allosteric agonists: Subtle structural changes abolish M(1) allosteric agonism and result in pan-mAChR orthosteric antagonism

Por Sheffler, Douglas J., Sevel, Christian, Le, Uyen, Lovell, Kimberly M., Tarr, James C., Carrington, Sheridan J. S., Cho, Hyekyung P., Digby, Gregory J., Niswender, Colleen M., Conn, P. Jeffrey, Hopkins, Corey R., Wood, Michael R., Lindsley, Craig W.
Publicado em 2012

Development of a Highly Potent, Novel M(5) Positive Allosteric Modulator (PAM) Demonstrating CNS Exposure: 1-((1H-Indazol-5-yl)sulfoneyl)-N-ethyl-N-(2-(trifluoromethyl)benzyl)piper...

Por Gentry, Patrick R., Kokubo, Masaya, Bridges, Thomas M., Noetzel, Meredith J., Cho, Hyekyung P., Lamsal, Atin, Smith, Emery, Chase, Peter, Hodder, Peter S., Niswender, Colleen M., Daniels, J. Scott, Conn, P. Jeffrey, Lindsley, Craig W., Wood, Michael R.
Publicado em 2014