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Synthesis and Biological Evaluation of Cremastrine and an Unnatural Analogue
In this Letter, we describe the first total synthesis of cremastrine, a pyrrolizidine alkaloid from Cremastra appendiculata, with anticholinergic activity as well as an unnatural analogue. The streamlined synthesis proceeds in 9 steps, 7 steps longest linear sequence, in 25.2% overall yield, and fea...
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| Autores principales: | , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2012
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3398747/ https://ncbi.nlm.nih.gov/pubmed/22822275 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tetlet.2012.05.009 |
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