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Re-exploration of the mGlu(1) PAM Ro 07-11401 scaffold: Discovery of analogs with improved CNS penetration despite steep SAR
This letter describes the re-exploration of the mGlu(1) PAM Ro 07-11401 scaffold through a multi-dimensional, iterative parallel synthesis approach. Unlike recent series of mGlu(1) PAMs with robust SAR, the SAR around the Ro 07-11401 structure was incredibly steep (only ~6 of 200 analogs displayed m...
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| Publicat a: | Bioorg Med Chem Lett |
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| Autors principals: | , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2016
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4833523/ https://ncbi.nlm.nih.gov/pubmed/27013388 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2016.03.044 |
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