Role of E166 in the imine to enamine tautomerization of the clinical β-lactamase inhibitor sulbactam

מאת Kalp, Matthew, Buynak, John D., Carey, Paul R.
יצא לאור 2009

Different intermediate populations formed by tazobactam, sulbactam, and clavulanate reacting with SHV-1 β-lactamases: Raman crystallographic evidence

מאת Kalp, Matthew, Totir, Monica A., Buynak, John D., Carey, Paul R.
יצא לאור 2009

Evaluation of β-Lactamase Inhibitors in Disk Tests for Detection of Plasmid-Mediated AmpC β-Lactamases in Well-Characterized Clinical Strains of Klebsiella spp.

מאת Black, Jennifer A., Thomson, Kenneth S., Buynak, John D., Pitout, Johann D. D.
יצא לאור 2005

Sulbactam Forms Only Minimal Amounts of Irreversible Acrylate-Enzyme With SHV-1 β-Lactamase

מאת Totir, Monica A., Helfand, Marion S., Carey, Marianne P., Sheri, Anjaneyulu, Buynak, John D., Bonomo, Robert A., Carey, Paul R.
יצא לאור 2007

Approaches to the simultaneous inactivation of metallo-and serine-β-lactamases

מאת Ganta, Sudhakar Reddy, Perumal, Senthil, Pagadala, Sundar Ram Reddy, Samuelsen, Ørjan, Spencer, James, Pratt, R. F., Buynak, John D.
יצא לאור 2009

Carboxylation and Decarboxylation of Active Site Lys 84 Controls the Activity of OXA-24 β-Lactamase of Acinetobacter baumannii: Raman Crystallographic and Solution Evidence

מאת Che, Tao, Bonomo, Robert A., Shanmugam, Sivaprakash, Bethel, Christopher R., Pusztai-Carey, Marianne, Buynak, John D., Carey, Paul R.
יצא לאור 2012

Structures of SHV-1 β-Lactamase with Penem and Penam Sulfone Inhibitors That Form Cyclic Intermediates Stabilized by Carbonyl Conjugation

מאת Ke, Wei, Pattanaik, Priyaranjan, Bethel, Christopher R., Sheri, Anjaneyulu, Buynak, John D., Bonomo, Robert A., van den Akker, Focco
יצא לאור 2012

Meropenem and Chromacef Intermediates Observed in IMP-25 Metallo-β-Lactamase-Catalyzed Hydrolysis

מאת Oelschlaeger, Peter, Aitha, Mahesh, Yang, Hao, Kang, Joon S., Zhang, Antonia L., Liu, Eleanor M., Buynak, John D., Crowder, Michael W.
הוצא לאור ב Antimicrob Agents Chemother (2015)

Virtual Screening and Experimental Testing of B1 Metallo-β-lactamase Inhibitors

מאת Kang, Joon S., Zhang, Antonia L., Faheem, Mohammad, Zhang, Charles J., Ai, Ni, Buynak, John D., Welsh, William J., Oelschlaeger, Peter
הוצא לאור ב J Chem Inf Model (2018)

Penam Sulfones and β-Lactamase Inhibition: SA2-13 and the Importance of the C2 Side Chain Length and Composition

מאת Rodkey, Elizabeth A., Winkler, Marisa L., Bethel, Christopher R., Pagadala, Sundar Ram Reddy, Buynak, John D., Bonomo, Robert A., van den Akker, Focco
יצא לאור 2014

Ligand-Dependent Disorder of the Ω Loop Observed in Extended-Spectrum SHV-Type β-Lactamase

מאת Sampson, Jared M., Ke, Wei, Bethel, Christopher R., Pagadala, S. R. R., Nottingham, Michael D., Bonomo, Robert A., Buynak, John D., van den Akker, Focco
יצא לאור 2011

Structure-Activity Relationships of Different β-Lactam Antibiotics against a Soluble Form of Enterococcus faecium PBP5, a Type II Bacterial Transpeptidase

מאת Hujer, Andrea M., Kania, Malgosia, Gerken, Thomas, Anderson, Vernon E., Buynak, John D., Ge, Xiaoxia, Caspers, Patrick, Page, Malcolm G. P., Rice, Louis B., Bonomo, Robert A.
יצא לאור 2005

Crystal Structures of KPC-2 β-Lactamase in Complex with 3-Nitrophenyl Boronic Acid and the Penam Sulfone PSR-3-226

מאת Ke, Wei, Bethel, Christopher R., Papp-Wallace, Krisztina M., Pagadala, Sundar Ram Reddy, Nottingham, Micheal, Fernandez, Daniel, Buynak, John D., Bonomo, Robert A., van den Akker, Focco
יצא לאור 2012

Activity of Imipenem, Meropenem, Cefepime, and Sulbactam in Combination with the β-Lactamase Inhibitor LN-1-255 against Acinetobacter spp.

מאת Lasarte-Monterrubio, Cristina, Vázquez-Ucha, Juan C., Maneiro, Maria, Arca-Suárez, Jorge, Alonso, Isaac, Guijarro-Sánchez, Paula, Buynak, John D., Bou, Germán, González-Bello, Concepción, Beceiro, Alejandro
הוצא לאור ב Antibiotics (Basel) (2021)

LN-1-255, a penicillanic acid sulfone able to inhibit the class D carbapenemase OXA-48

מאת Vallejo, Juan A., Martínez-Guitián, Marta, Vázquez-Ucha, Juan C., González-Bello, Concepción, Poza, Margarita, Buynak, John D., Bethel, Christopher R., Bonomo, Robert A., Bou, German, Beceiro, Alejandro
הוצא לאור ב J Antimicrob Chemother (2016)

The importance of the trans-enamine intermediate as a β-lactamase inhibition strategy probed in inhibitor-resistant SHV β-lactamase variants

מאת Ke, Wei, Rodkey, Elizabeth A., Sampson, Jared M., Skalweit, Marion J., Sheri, Anjaneyulu, Pagadala, Sundar Ram Reddy, Nottingham, Michael D., Buynak, John D., Bonomo, Robert A., van den Akker, Focco
יצא לאור 2012

Rational design of a β-lactamase inhibitor achieved via stabilization of the trans-enamine intermediate: 1.28 Å crystal structure of wt SHV-1 complex with a penam sulfone

מאת Padayatti, Pius S., Sheri, Anjaneyulu, Totir, Monica A., Helfand, Marion S., Carey, Marianne P., Anderson, Vernon A., Carey, Paul R., Bethel, Christopher R., Bonomo, Robert A., Buynak, John D., van den Akker, Focco
יצא לאור 2006

Modifications of the C6-Substituent of Penicillin Sulfones with the Goal of Improving Inhibitor Recognition and Efficacy

מאת Nottingham, Micheal, Bethel, Christopher R., Pagadala, Sundar Ram Reddy, Harry, Emily, Pinto, Abishai, Lemons, Zachary A., Drawz, Sarah M., van den Akker, Focco, Carey, Paul R., Bonomo, Robert A., Buynak, John D.
יצא לאור 2010

β-Lactamase Inhibition by 7-Alkylidenecephalosporin Sulfones: Allylic Transposition and Formation of an Unprecedented Stabilized Acyl-Enzyme

מאת Rodkey, Elizabeth A., McLeod, David C., Bethel, Christopher R., Smith, Kerri M., Xu, Yan, Chai, Weirui, Che, Tao, Carey, Paul R., Bonomo, Robert A., van den Akker, Focco, Buynak, John D.
יצא לאור 2013

Detecting a Quasi-stable Imine Species on the Reaction Pathway of SHV-1 β-Lactamase and 6β-(Hydroxymethyl)penicillanic Acid Sulfone

מאת Che, Tao, Rodkey, Elizabeth A., Bethel, Christopher R., Shanmugam, Sivaprakash, Ding, Zhe, Pusztai-Carey, Marianne, Nottingham, Michael, Chai, Weirui, Buynak, John D., Bonomo, Robert A., van den Akker, Focco, Carey, Paul R.
הוצא לאור ב Biochemistry (2014)